Note This can be done for the Default Website if desired.
.Net comes pre-configured for invariant culture which means that by default the culture of the server application is en-US, which means that any date-conversion functions employed work with US date formats.
From the Features page, select .Net Globalization, and then change options Culture and UI Culture to the preferred specific locale, such as English (United Kingdom) (en-GB).
An example impact of not doing this is that when preparing a report or query to be used by SAXT, SAXT Updater will compare dates using the current locale as set in the region options for the system, but SAXT Reader would compare dates assuming they are given in US format – so the reports can give different results.